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What (who) is 2-hydroxyquinoline 5,6-dioxygenase - definition
2-hydroxyquinoline 5,6-dioxygenase
In enzymology, a 2-hydroxyquinoline 5,6-dioxygenase () is an enzyme that catalyzes the chemical reaction
Alpha-ketoglutarate-dependent hydroxylases
![prolyl hydroxylase isoform 2]] (PHD2), a human αKG-dependent dioxygenase. The Fe(II) is coordinated by two imidazoles and one carboxylate provided by the protein. Other ligands on iron, which are transiently occupied αKG and O<sub>2</sub>, are omitted for clarity.](https://commons.wikimedia.org/wiki/Special:FilePath/PHD2 iron binding site.png?width=200 "prolyl hydroxylase isoform 2]] (PHD2), a human αKG-dependent dioxygenase. The Fe(II) is coordinated by two imidazoles and one carboxylate provided by the protein. Other ligands on iron, which are transiently occupied αKG and O<sub>2</sub>, are omitted for clarity.")
CLASS OF ENZYMES
2-oxoglutarate (2OG)-dependent dioxygenases; Alpha-ketoglutarate-dependent hydroxylase; 2-oxoglutarate–dependent dioxygenase; 2-oxoglutarate-dependent dioxygenase
Alpha-ketoglutarate-dependent hydroxylases are a major class of non-heme iron proteins that catalyse a wide range of reactions. These reactions include hydroxylation reactions, demethylations, ring expansions, ring closures, and desaturations.
Lysyl hydroxylase
CLASS OF ENZYMES
Procollagen-lysine 5-dioxygenase; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase; Lysyl 5-hydroxylase; PLOD1; EC 1.14.11.4; L-lysine-(procollagen),2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Lysyl hydroxylases (or procollagen-lysine 5-dioxygenases) are alpha-ketoglutarate-dependent hydroxylases enzymes that catalyze the hydroxylation of lysine to hydroxylysine. Lysyl hydroxylases require iron and vitamin C as cofactors for their oxidation activity.
